αv Integrin-Targeted Immunoconjugates Regress Established Human Tumors in Xenograft Models
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چکیده
منابع مشابه
αV Integrin Induces Multicellular Radioresistance in Human Nasopharyngeal Carcinoma via Activating SAPK/JNK Pathway
BACKGROUND Tumor cells acquire the capacity of resistance to chemotherapy or radiotherapy via cell-matrix and cell-cell crosstalk. Integrins are the most important cell adhesion molecules, in which αV integrin mainly mediating the tight contact between tumor cells. METHODOLOGY/PRINCIPAL FINDINGS To investigate the role of αV integrin in multi-cellular radioresistance (MCR) of human nasopharyn...
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Leigh Ellis and Massimo Loda Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263; Department of Medical Oncology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, MA 02115...
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DNA damage responses (DDR) occur during oncogenesis and therapeutic responses to DNA damaging cytotoxic drugs. Thus, a real-time method to image DNA damage in vivo would be useful to diagnose cancer and monitor its treatment. Toward this end, we have developed fluorophore- and radioisotope-labeled immunoconjugates to target a DDR signaling protein, phosphorylated histone H2A variant H2AX (γH2AX...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2007
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-07-0026